If
any organism produces immune response against its own healthy cells and tissue
systems, then the phenomenon is known as Autoimmunity and the disease from such
an aberrant immune response that results is termed an "autoimmune
disease".
Immunodeficiency and Autoimmunity:
Clinical
and laboratory characteristics of autoimmunity
are presented in large numbers by immunodeficiency syndromes. Autoimmunity
through perpetual immune system activation may be caused to clear infections in
these patients by the decreased ability of the immune system. Autoimmune
thyroid disease, autoimmune thrombocytopenia and inflammatory bowel are the multiple
autoimmune diseases seen from common variable immunodeficiency.
Diagnosis:
It
can be diagnosed on an accurate history and physical examination of the patient
and even on certain abnormalities in routine laboratory tests. In many of the
systemic disorders, specific autoantibodies can be detected from serological
assays, whereas immunofluorescence
of biopsy specimens is the best to diagnose localised disorders. And autoimmune
diseases are diagnosed by many Autoantibodies and these levels are measured to
determine the progress of the disease.
Treatments:
Autoimmune
disease treatments have traditionally been anti-inflammatory, palliative, or immunosuppressive.
In autoimmune diseases inflammation managing is highly critical. These are palliative treatments as the outcomes are autoaggressive responses in
cases such as hormone replacement in Hashimoto's thyroiditis or Type 1 diabetes
mellitus which are non-immunological therapies. TNFα antagonists, the B cell
depleting agent rituximab which are immunomodulatory therapies are shown to be
useful in treating Rheumatoid arthritis which indeed these immunotherapies will
be associated with increased risk to infection.
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